脂类学
高密度脂蛋白
胆固醇
蛋白质组学
脂蛋白
疾病
计算生物学
流出
医学
生物信息学
生物
内科学
生物化学
基因
作者
Bela F. Asztalos,Katrin Niisuke,Katalin V. Horvath
出处
期刊:Current Opinion in Lipidology
[Ovid Technologies (Wolters Kluwer)]
日期:2019-08-01
卷期号:30 (4): 314-319
被引量:10
标识
DOI:10.1097/mol.0000000000000612
摘要
Purpose of review Despite advances in the research on HDL composition (lipidomics and proteomics) and functions (cholesterol efflux and antioxidative capacities), the relationship between HDL compositional and functional properties is not fully understood. We have reviewed the recent literature on this topic and pointed out the difficulties which limit our understanding of HDL's role in cardiovascular disease (CVD). Recent findings Though current findings strongly support that HDL has a significant role in CVD, the underlying mechanisms by which HDL mitigates CVD risk are not clear. This review focuses on studies that investigate the cell-cholesterol efflux capacity and the proteomic and lipidomic characterization of HDL and its subfractions especially those that analyzed the relationship between HDL composition and functions. Summary Recent studies on HDL composition and HDL functions have greatly contributed to our understanding of HDL's role in CVD. A major problem in HDL research is the lack of standardization of both the HDL isolation and HDL functionality methods. Data generated by different methods often produce discordant results on the particle number, size, lipid and protein composition, and the various functions of HDL.
科研通智能强力驱动
Strongly Powered by AbleSci AI