医学
微卫星不稳定性
彭布罗利珠单抗
无容量
肿瘤科
内科学
结直肠癌
免疫检查点
生物标志物
癌症研究
癌症
免疫疗法
微卫星
基因
等位基因
化学
生物化学
作者
Alexa B. Schrock,Ching Ouyang,Jaideep Sandhu,Ethan S. Sokol,Dexter X. Jin,Jeffrey S. Ross,V.A. Miller,Dean Lim,Idoroenyi Amanam,Joseph Chao,Daniel V.T. Catenacci,M. Cho,Fadi Braiteh,Samuel J. Klempner,Siraj M. Ali,Marwan Fakih
标识
DOI:10.1093/annonc/mdz134
摘要
Microsatellite instability (MSI) is a biomarker for response to immune checkpoint inhibitors (ICPIs). PD-1 inhibitors in metastatic colorectal carcinoma (mCRC) with MSI-high (MSI-H) have demonstrated a high disease control rate and favorable progression-free survival (PFS); however, reported response rates to pembrolizumab and nivolumab are variable and often <50%, suggesting that additional predictive biomarkers are needed.
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