化学
四氢萘酮
分子
氢
光化学
组合化学
相容性(地球化学)
能量转移
立体化学
有机化学
化学物理
化学工程
工程类
作者
Yongbo Tan,Jing Zhao,Guo‐Jun Deng,Xiaochen Ji,Huawen Huang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-03-18
卷期号:26 (12): 2398-2402
被引量:1
标识
DOI:10.1021/acs.orglett.4c00504
摘要
Herein, we introduce a tetralone-mediated photocyclization method of N-arylacrylamides. The protocol proceeds smoothly to deliver a diverse set of 3,4-dihydroquinolinones in moderate to good yields with excellent functional group compatibility and readily allows for late-stage modifications of a number of complex drug molecules. Mechanistic studies reveal that the present systems with ultraviolet light irradiation enable the cyclization via energy transfer and exclusive 1,3-hydrogen shift.
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