转移
癌症研究
乳腺癌
细胞凋亡
三阴性乳腺癌
癌症
基因剔除小鼠
医学
恶性肿瘤
体内
生物
内科学
受体
生物化学
生物技术
作者
Yuanxing Han,Nueryemu Maimaiti,Yan Sun,Juan Yao
标识
DOI:10.1007/s10735-023-10178-x
摘要
Abstract The histone lysine demethylase 3 A (KDM3A) is vital for the regulation of cancer physiology and pathophysiology. The purpose of this study was to investigate the effect of KDM3A expression with triple-negative breast cancer (TNBC) invasion and metastasis. In our results, knockout of KDM3A in TNBC MDA-MB-231 cells promoted apoptosis and inhibited the proliferation, invasion and metastasis of MDA-MB-231 cells. In addition, we found that in vivo experiments indicated that the growth, invasion and metastasis of metastatic neoplasms were significantly inhibited by knockout of KDM3A in a TNBC metastasis model. These findings suggest that KDM3A may be a potential therapeutic target for the treatment and prevention of TNBC, providing a critical theoretical basis for the effective prevention or treatment of breast cancer disease.
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