化学
芳基
电泳剂
催化作用
镍
亲核细胞
磺胺
溴化物
组合化学
磺酸盐
药物化学
有机化学
钠
烷基
作者
Samuel A. Fisher,Connor M. Simon,Peter L. Fox,Michael J. Cotnam,Patrick DeRoy,Mark Stradiotto
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-02-08
卷期号:26 (7): 1326-1331
被引量:1
标识
DOI:10.1021/acs.orglett.3c04152
摘要
We report a versatile method for cross-coupling of NH-sulfoximines with (hetero)aryl chlorides, as well as bromide and sulfonate electrophiles, that makes use of the air-stable, commercial precatalyst (PhPAd-DalPhos)Ni(o-tol)Cl. Under optimized conditions a diverse electrophile scope is established, including the N-arylation of the pharmaceutical Clozapine. While 5 mol % Ni and 80 °C are commonly employed in this chemistry, successful examples utilizing 1 mol % Ni and/or 25 °C are presented. Competition experiments establish the superiority of NH-sulfoximine over primary sulfonamide as nucleophiles under these conditions.
科研通智能强力驱动
Strongly Powered by AbleSci AI