Integrating multi-omics features for blood-based multi-cancer early detection.

癌症 医学 乳腺癌 胰腺癌 内科学 肺癌 肿瘤科 人口 阶段(地层学) 胃癌 无症状的 肝癌 生物 环境卫生 古生物学
作者
Mao Mao,Shiyong Li,Qingqi Ren,Yi Luan,Weijie Liang,Shuaipeng Geng,Guolin Zhong,Dandan Zhu,Yinyin Chang,Wei Wu,Yingying Zhang,Linfeng Zhang,Yan Wang,Yukuan Feng,Bing Wei,Jie Ma,Chaohui Duan,Guanghui Long
出处
期刊:JCO global oncology [American Society of Clinical Oncology]
卷期号:9 (Supplement_1): 156-156
标识
DOI:10.1200/go.2023.9.supplement_1.156
摘要

156 Background: The current standard-of-care cancer screening paradigm is constrained to just a few cancer types and has challenges in patient compliance due to the invasive procedures endured from the tests. Recently studies have demonstrated that blood-based multi-cancer detection (MCED) approaches may hold promise for identifying asymptomatic cancer patients from the general population. However, most studies only exploit a single aspect of cancer hallmarks which is challenging for the biological reasons since cancer is a heterogenous disease with a wide spectrum of pathological and clinical behaviors. Methods: Here we report SeekInCare, a CE-IVD Mark MCED test, based on a novel multi-dimensional cancer risk score (CRS) model incorporating copy number aberrations, fragment size, end motifs and oncogenic viruses via shallow whole genome sequencing (sWGS) from cell-free DNA (cfDNA), and seven common tumor markers in a single 8ml blood draw. Results: Our research cohort consisted of 898 healthy subjects and 615 stage I-IV cancer patients that covered eight common cancers and 19 uncommon cancer types. The CRS model identified 427 cancer patients with 69.4% sensitivity at 98.0% specificity, resulting in an AUC (area under the curve) of 0.926. The sensitivities were 50.3%, 64.0%, 73.8% and 86.2% in stage I, II, III and IV cancers respectively. The sensitivities of eight common cancer types, breast, stomach, lung, colorectum, lymphoma, liver, pancreas and leukemia, were 45.1%, 50.0%, 63.4%, 69.4%, 70.5%, 81.4%, 82.4% and 90.9% respectively. We also prospectively evaluated SeekInCare in a real-world cohort consisting of 1212 subjects who received the test as a LDT (laboratory developed test) (median follow-up time: 753 days, range: 78~1669 days). 13 out of 18 cancer cases were detected while 46 subjects tested positive but without cancer. Thus, SeekInCare achieved 72.2% sensitivity, 96.1% specificity, 22.0% PPV and 99.6% NPV in the real-world cohort. Conclusions: In this study, we provided a non-invasive MCED test (SeekInCare) based on the multi-omics and multi-dimensional features. The case-control study demonstrated that SeekInCare could detect >20 cancer types with 69.4% sensitivity at 98.0% specificity. The outstanding real-world performance of SeekInCare warrants future investigation of its clinical utility and health economics as a mass cancer screening test in average-risk populations.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
丘比特应助海带采纳,获得10
刚刚
1秒前
落寞丹萱发布了新的文献求助10
1秒前
山海之间完成签到,获得积分10
2秒前
TRY发布了新的文献求助10
2秒前
生姜完成签到 ,获得积分10
2秒前
2041完成签到,获得积分10
4秒前
飘逸踏歌完成签到 ,获得积分0
7秒前
充电宝应助落寞丹萱采纳,获得10
7秒前
yanshapo发布了新的文献求助10
8秒前
脑洞疼应助发疯的游子采纳,获得10
10秒前
888发布了新的文献求助20
10秒前
SYLH完成签到,获得积分0
11秒前
lrj完成签到,获得积分20
11秒前
海带完成签到,获得积分10
11秒前
天天快乐应助笨笨的晓夏采纳,获得10
12秒前
高大小懒猪完成签到,获得积分10
13秒前
16秒前
大气的火龙果完成签到 ,获得积分10
16秒前
Charles完成签到,获得积分10
16秒前
薛洁洁的小糖应助888采纳,获得50
16秒前
紫色水晶之恋完成签到 ,获得积分10
18秒前
yanshapo完成签到,获得积分10
21秒前
23秒前
山海发布了新的文献求助10
23秒前
大海的DOI完成签到,获得积分10
24秒前
24秒前
火星上白羊完成签到 ,获得积分10
29秒前
小蘑菇应助科研通管家采纳,获得10
29秒前
研友_VZG7GZ应助科研通管家采纳,获得10
29秒前
梁三柏应助科研通管家采纳,获得20
29秒前
田様应助科研通管家采纳,获得10
29秒前
29秒前
桐桐应助科研通管家采纳,获得10
29秒前
汉堡包应助科研通管家采纳,获得10
29秒前
赤木完成签到 ,获得积分10
30秒前
海带发布了新的文献求助10
31秒前
女神金完成签到,获得积分10
32秒前
34秒前
山海完成签到,获得积分10
35秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3572296
求助须知:如何正确求助?哪些是违规求助? 3142501
关于积分的说明 9448015
捐赠科研通 2843973
什么是DOI,文献DOI怎么找? 1563103
邀请新用户注册赠送积分活动 731630
科研通“疑难数据库(出版商)”最低求助积分说明 718640