Retinoic acid ameliorates low-grade endotoxemia-induced mastitis by limiting inflammatory responses in mice

乳腺炎 封堵器 促炎细胞因子 发病机制 免疫学 免疫系统 炎症 维甲酸 医学 内分泌学 生物 紧密连接 生物化学 病理 基因
作者
Keyi Wu,Shang Shan,Lijuan Bao,Yihong Zhao,Zhihang Guan,Jiawen Xu,Hao Sun,Yuan Wei‐jie,Yunhe Fu,Lu-Yuan Peng,Caijun Zhao
出处
期刊:Microbial Pathogenesis [Elsevier]
卷期号:185: 106426-106426 被引量:1
标识
DOI:10.1016/j.micpath.2023.106426
摘要

Mastitis is a serious disease for humans and animals, which causes huge economic losses in the dairy industry and is hard to prevent due to the complex and unclear pathogenesis. Subacute ruminal acidosis (SARA) has contributed to the development of mastitis by inducing ruminal dysbiosis and subsequent low-grade endotoxemia (LGE), however, how ruminal metabolic changes regulate this progress is still unclear. Our previous study revealed that cows with SARA had increased ruminal retinoic acid (RA) levels, a metabolic intermediate of vitamin A that plays an essential role in mucosal immune responses. Hence, the aim of this study was to investigate the protective effect of RA on LGE-induced mastitis and the underlying mechanisms in mice. The results showed that RA alleviated LGE-induced mastitis, as evidenced by RA significantly reduced the increase in mammary proinflammatory cytokines and improved blood-milk barrier injury caused by LGE. In addition, RA increased the expression of tight junction proteins, including ZO-1, occludin and claudin-3. Furthermore, we found that RA limited the mammary inflammatory responses by inhibiting the activation of NF-κB and NLRP3 signaling pathways. These findings suggest that RA effectively alleviates LGE-induced mastitis and implies a potential strategy for the treatment and prevention of mastitis and other diseases.
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