Long-Term Risk of Acute Myocardial Infarction in Patients With a Transient Ischemic Attack: A Danish Nationwide Cohort Study

医学 心肌梗塞 危险系数 人口 冲程(发动机) 内科学 比例危险模型 队列 队列研究 共病 心脏病学 置信区间 机械工程 工程类 环境卫生
作者
Hazim J. Safi,Søren Lund Kristensen,Rikke Sørensen,Christina Kruuse,Søren Paaske Johnsen,Gunnar Gislason,Christian Torp‐Pedersen,Lars Køber,Emil Loldrup Fosbøl,Naja Emborg Vinding
出处
期刊:Stroke [Lippincott Williams & Wilkins]
标识
DOI:10.1161/strokeaha.123.045605
摘要

BACKGROUND: Sparse information regarding the long-term risk of acute myocardial infarction (MI) following a transient ischemic attack (TIA) emphasizes further research to guide preventive strategies and risk stratification in patients with a TIA. METHODS: We conducted a nationwide cohort study to investigate the 5-year risk of MI and all-cause mortality in patients with a first-time TIA. Patients with a first-time TIA were identified in the Danish Stroke Registry (2013–2020), matched on age, sex, and calendar year (1:4) with the general population and (1:1) with patients with first-time ischemic stroke. The 5-year risks of MI and all-cause mortality were estimated by the Aalen-Johansen and Kaplan-Meier estimators. The groups were compared using Cox regression, while adjusting for cardiovascular comorbidities. RESULTS: We identified 21 743 patients with TIA, 86 972 matched individuals from the general population, and 21 743 matched control patients with ischemic stroke. Median age was 70 (25th to 75th percentile, 60–78) years; 52% were male. Comorbidity burden was the lowest in general population controls, intermediate in patients with TIA, and the highest in patients with ischemic stroke. The 5-year risk of MI was 2.0% in patients with TIA, 1.5% in the general population ( P <0.001), and 2.2% in the ischemic stroke population ( P <0.001). After adjustment, these differences in MI rate were similar (TIA versus general population; hazard ratio, 0.99 [95% CI, 0.98–1.02] and TIA versus ischemic stroke; hazard ratio, 0.99 [95% CI, 0.96–1.01]). The 5-year risk of mortality was 17.0% in patients with TIA compared with 14.0% in the general population ( P <0.001) and 27.0% in ischemic stroke population ( P <0.001). The differences in mortality persisted following adjustments for patients with TIA versus general population (hazard ratio, 1.25 [95% CI, 1.19–1.31]) and for patients with TIA versus ischemic stroke (hazard ratio, 0.43 [95% CI, 0.41–0.46]). CONCLUSIONS: Patients with first-time TIA had a low 5-year incidence of MI, which was not significantly different from that of the general population and patients with first-time ischemic stroke after adjustments for comorbidities. However, patients with TIA had a 25% higher all-cause mortality rate than the general population, which was not readily explained by MI risk. Hence, the findings do not endorse the need to raise further awareness regarding MI in patients with TIA.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yin景景给yin景景的求助进行了留言
刚刚
3秒前
小魏哥完成签到,获得积分10
7秒前
9秒前
9秒前
10秒前
12秒前
16秒前
zhou默完成签到,获得积分10
16秒前
英姑应助clcl采纳,获得10
19秒前
研友_LX66qZ完成签到,获得积分10
19秒前
ran发布了新的文献求助10
22秒前
搜集达人应助大罗采纳,获得10
22秒前
量子星尘发布了新的文献求助10
23秒前
CipherSage应助Dai采纳,获得30
24秒前
科研通AI5应助王佳亮采纳,获得10
26秒前
27秒前
30秒前
英姑应助Sea_U采纳,获得10
31秒前
金金金完成签到,获得积分10
32秒前
cobo完成签到,获得积分10
33秒前
肖肖发布了新的文献求助10
34秒前
Rondab应助准炮打不准采纳,获得10
35秒前
ran完成签到,获得积分10
35秒前
遇上就这样吧应助YSJ采纳,获得10
36秒前
36秒前
朱1591完成签到,获得积分10
38秒前
研友_VZG7GZ应助战斗暴龙兽采纳,获得10
40秒前
40秒前
40秒前
43秒前
YJ888发布了新的文献求助10
43秒前
c_123发布了新的文献求助10
44秒前
SYLH应助科学宝宝☜采纳,获得10
45秒前
clcl发布了新的文献求助10
45秒前
可爱蓝天完成签到,获得积分10
47秒前
顾矜应助东方红采纳,获得30
47秒前
俭朴的听寒完成签到,获得积分10
48秒前
王了了完成签到 ,获得积分10
49秒前
51秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989069
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253589
捐赠科研通 3269939
什么是DOI,文献DOI怎么找? 1804851
邀请新用户注册赠送积分活动 882074
科研通“疑难数据库(出版商)”最低求助积分说明 809073