自愈水凝胶
壳聚糖
伤口愈合
血管生成
止血
血管内皮生长因子A
生物医学工程
化学
医学
血管内皮生长因子受体
血管内皮生长因子
癌症研究
免疫学
外科
生物化学
有机化学
作者
Sabrina Schaly,Paromita Islam,Ahmed Abosalha,Jacqueline L. Boyajian,Dominique Shum‐Tim,Satya Prakash
出处
期刊:Pharmaceuticals
[MDPI AG]
日期:2022-11-10
卷期号:15 (11): 1382-1382
被引量:18
摘要
Hydrogel wound dressings are effective in their ability to provide a wound-healing environment but are limited by their ability to promote later stages of revascularization. Here, a biosafe recombinant baculovirus expressing VEGFA tagged with EGFP is encapsulated in chitosan-coated alginate hydrogels using ionic cross-linking. The VEGFA, delivered by the baculovirus, significantly improves cell migration and angiogenesis to assist with the wound-healing process and revascularization. Moreover, the hydrogels have an encapsulation efficiency of 99.9%, no cytotoxicity, antimicrobial properties, good blood compatibility, promote hemostasis, and enable sustained delivery of baculoviruses over eight days. These hydrogels sustain baculovirus delivery and may have clinical implications in wound dressings or future gene therapy applications.
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