Datacenters towards low carbon emission, low energy consumption, green energy saving, and sustainability has become the trends. Using 48V as the intermediate bus perfectly meets these trends. 48V brings advantages to server power delivery, but there are many high-speed signals routed in the server mother board, those traces are sensitive to noise caused by Voltage Regulator (VR). Currently, 4SV only exists in some special areas of the motherboard. This paper will introduce an innovative study to use two stage power architecture with 48V rack. Based on this architecture, we have compared distribution loss and PCI Express * IO Margin Test (IOMT) and studied noise coupling of 12V and 4SV within same Printed Circuit Board (PCB).