生物
紫杉醇
卵巢癌
癌症研究
药理学
内科学
癌症
遗传学
医学
作者
Fangquan Chen,Junhao Lin,Rui Kang,Daolin Tang,Jiao Liu
摘要
Paclitaxel serves as the cornerstone chemotherapy for ovarian cancer, yet its prolonged administration frequently culminates in drug resistance, presenting a substantial challenge. Here we reported that inducing alkaliptosis, rather than apoptosis or ferroptosis, effectively overcomes paclitaxel resistance. Mechanistically, ATPase H
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