结核分枝杆菌
免疫系统
免疫学
肺结核
表型
效应器
接种疫苗
卡介苗
T细胞
生物
细胞毒性T细胞
病毒学
医学
遗传学
体外
病理
基因
作者
One Dintwe,Lamar Ballweber-Fleming,Valentin Voillet,John McNevin,Aaron Seese,Anneta Naidoo,Saleha Omarjee,Linda‐Gail Bekker,James G. Kublin,Stephen C. De Rosa,Evan W. Newell,Andrew Fioré-Gartland,Erica Andersen‐Nissen,M. Juliana McElrath
标识
DOI:10.1038/s41467-024-49050-1
摘要
Abstract A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis ( M.tb ). In a companion phase 1b trial, HVTN 602/Aeras A-042, we characterize in-depth the cellular responses to BCG revaccination or to a H4:IC31 vaccine boost to identify T cell subsets that could be responsible for the protection observed. High-dimensional clustering analysis of cells profiled using a 26-color flow cytometric panel show marked increases in five effector memory CD4 + T cell subpopulations (T EM ) after BCG revaccination, two of which are highly polyfunctional. CITE-Seq single-cell analysis shows that the activated subsets include an abundant cluster of Th1 cells with migratory potential. Additionally, a small cluster of Th17 T EM cells induced by BCG revaccination expresses high levels of CD103; these may represent recirculating tissue-resident memory cells that could provide pulmonary immune protection. Together, these results identify unique populations of CD4 + T cells with potential to be immune correlates of protection conferred by BCG revaccination.
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