NADPH氧化酶
氧化应激
安普克
泡沫电池
氧化磷酸化
化学
葡萄糖氧化酶
细胞生物学
生物化学
酶
巨噬细胞
生物
蛋白激酶A
体外
作者
Michishige Terasaki,Hironori Yashima,Yusaku Mori,Tomomi Saito,Naoto Inoue,Takanori Matsui,Naoya Osaka,Tomoki Fujikawa,Makoto Ohara,Sho‐ichi Yamagishi
摘要
Glucose-dependent insulinotropic polypeptide (GIP) of the incretin group has been shown to exert pleiotropic actions. There is growing evidence that advanced glycation end products (AGEs), senescent macromolecules formed at an accelerated rate under chronic hyperglycemic conditions, play a role in the pathogenesis of atherosclerotic cardiovascular disease in diabetes. However, whether and how GIP could inhibit the AGE-induced foam cell formation of macrophages, an initial step of atherosclerosis remains to be elucidated. In this study, we address these issues. We found that AGEs increased oxidized low-density-lipoprotein uptake into reactive oxygen species (ROS) generation and
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