Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study

This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving post-operative extracorporeal membrane oxygenation (ECMO) support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor ECMO outcomes.