Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

Abstract Nowadays successful application of nanoparticles for therapeutic objects needs the effective uptake of them by cells. Hence, studying of the interaction of nanoparticles with cell membrane for effective cellular uptaking seems to be vital and important. Trafficking of lipids, proteins, glucose, and other biomaterials into the cells is possible from two major exocytic and endocytic pathways. The penetration ability of nanoparticles into the cells must be considered in engineering of these particles. Enormous in vivo and in vitro experiments in the field of nanotechnology have confirmed the effect of physiochemistry properties in state of cell‐nanoparticles interactions. Thus, the optimization of parameters directly related to physicochemical characteristics through the preparation process seems to be necessary for improving therapeutic effects of nanocarriers. Besides, biological medium and cell division also affect the amount of nanoparticle uptaking into the cells. This study reviews the influence of size, shape, the surface modification of nano particles, medium, and cell division effects on the cellular absorption of drug/gene nanocarriers.