FLUOTHANE COMPARED TO CHLOROFORM AND ETHER IN MICE

SUMMARY Fluothane was compared to chloroform and diethyl ether in mice to determine its anesthetic potency and margin of safety. The anesthetic was mixed with air in known concentrations. Fluothane and chloroform produced similar anesthesia, and was 4 1/2 times more potent than ether. Induction with fluothane was faster than with chloroform and ether. Fluothane seems slightly more potent than chloroform and has an equal margin of safety. The margin of safety expressed as the ratio of LD 50 to AD 50 was 2 for fluothane and chloroform, 2.25 for ether. Recovery from fluothane and chloroform was about equal and much faster than from ether.