真菌性角膜炎
角膜炎
趋化因子
免疫学
免疫系统
炎症
免疫
模式识别受体
促炎细胞因子
受体
角膜
生物
微生物学
神经科学
遗传学
生物化学
出处
期刊:Chinese Journal of Optometry & Ophthalmology
日期:2010-06-25
卷期号:12 (03): 237-240
标识
DOI:10.3760/cma.j.issn.1674-845x.2010.03.020
摘要
Fungal keratitis, a common cause of cornea] infectious diseases, is an important contributor to vision loss. Toxins and exoenzymes released from infiltrating fungi led to damage of the comea. Matrix metalloproteinases played an important role in fungal keratitis. Recognition of fungi by pattern-recognition receptors such as Toll-like receptors mediated the host to produce initiate and adaptive immune responses. Immunoprotection and inflammatory reaction which include numerous cells, cytokines and chemokines were involved in the responses of comea versus invading fungi. The cells and cytokines could protect cornea from fungi invasion but also cause some damage. The final outcome was depended upon the balance between impaired factors and repaired factors. A better understanding of molecular mechanism of the immunity and inflammation will provide new ideas for the treatment of fungal keratitis. The molecular mechanism of fungal keratitis was reviewed in this article.
Key words:
Keratitis; Eye infections,fungal; Immunity; Cytokines; Chemokines
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