The Impact of Age and Gender on Outcomes of Patients With Advanced Renal Cell Carcinoma Treated With Targeted Therapy

医学 肾细胞癌 不利影响 内科学 比例危险模型 肿瘤科 癌症 年轻人 临床试验
作者
Justine Panian,Xun Lin,Ronit Simantov,Ithaar Derweesh,Toni K. Choueiri,Rana R. McKay
出处
期刊:Clinical Genitourinary Cancer [Elsevier BV]
卷期号:18 (5): e598-e609 被引量:12
标识
DOI:10.1016/j.clgc.2020.03.010
摘要

A growing body of evidence suggests that age and gender play a role in cancer outcomes. The objective of this study was to investigate the effect of age and gender on survival of patients with metastatic renal cell carcinoma (RCC).We conducted a pooled analysis of patients with metastatic RCC treated on phase II and III clinical trials. Patients were stratified by age (young [<50 years], intermediate [50-70 years], versus elderly [>70 years]) and gender. Statistical analyses were performed using Cox regression adjusted for several risk factors and the Kaplan-Meier method.We identified 4736 patients with metastatic RCC. Overall, there was no difference in overall survival (OS) when stratified by age (21.0 vs. 17.3 months for elderly vs. intermediate age groups, P = .382; 20.0 vs. 17.3 months for young vs. intermediate age groups, P = .155) or gender (19.8 vs. 19.0 for male vs. female, P = .510). Progression-free survival (PFS) was shorter in younger individuals compared with the intermediate age patients (6.0 vs. 7.1 months, P < .001), but similar across gender groups. Although all grade adverse events were more common in elderly patients (fatigue, diarrhea, decreased appetite, and weight), serious adverse events were similar between groups.Although OS was similar between age groups, younger individuals had a shorter PFS. Gender was not an independent determinant of survival. Elderly patients experienced more adverse events than their younger counterparts. These findings are important to guide clinicians when counseling patients about expectations and toxicity associated with therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
HtObama完成签到,获得积分10
1秒前
小欢完成签到,获得积分10
1秒前
小鹅呀完成签到,获得积分10
2秒前
沟通亿心完成签到,获得积分10
2秒前
果果完成签到,获得积分10
3秒前
Panchael完成签到,获得积分10
3秒前
3秒前
小井盖完成签到 ,获得积分10
5秒前
热情的元芹完成签到,获得积分10
5秒前
6秒前
陶醉的小海豚完成签到,获得积分10
7秒前
陆晓亦完成签到,获得积分10
7秒前
乐观的觅松完成签到,获得积分10
7秒前
2023204306324发布了新的文献求助10
8秒前
9秒前
端己完成签到,获得积分20
9秒前
10秒前
阿湫发布了新的文献求助10
10秒前
11秒前
11秒前
坤坤完成签到,获得积分10
11秒前
12秒前
STUSSY完成签到,获得积分10
12秒前
wuhuofeng发布了新的文献求助10
13秒前
14秒前
15秒前
15秒前
coco完成签到,获得积分10
16秒前
lshao完成签到 ,获得积分10
17秒前
17秒前
zhou发布了新的文献求助30
18秒前
跋扈完成签到,获得积分10
20秒前
温柔翰发布了新的文献求助10
20秒前
20秒前
Jj发布了新的文献求助10
21秒前
ficus_min发布了新的文献求助10
21秒前
木子发布了新的文献求助10
22秒前
Galato发布了新的文献求助10
22秒前
寒冷哈密瓜完成签到 ,获得积分0
22秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048