间质细胞
神经科学
癌症
感觉系统
医学
发病机制
生物
病理
内科学
作者
Ali H. Zahalka,Paul S. Frenette
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2020-01-23
卷期号:20 (3): 143-157
被引量:258
标识
DOI:10.1038/s41568-019-0237-2
摘要
The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies have shown that peripheral nerves (sympathetic, parasympathetic and sensory) interact with tumour and stromal cells to promote the initiation and progression of a variety of solid and haematological malignancies. Furthermore, new evidence suggests that cancers may reactivate nerve-dependent developmental and regenerative processes to promote their growth and survival. Here we review emerging concepts and discuss the therapeutic implications of manipulating nerves and neural signalling for the prevention and treatment of cancer. This Review discusses the role that nerves play in the initiation and progression of cancers, focusing on the evidence that tumours may reactivate nerve-mediated developmental and regenerative pathways to promote their own growth and survival.
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