伦瓦提尼
医学
肝细胞癌
核医学
正电子发射断层摄影术
磁共振成像
内科学
胃肠病学
放射科
索拉非尼
作者
Yusuke Kawamura,Masahiro Kobayashi,Junichi Shindoh,Yuta Kobayashi,Kayoko Kasuya,Tomoya Sano,Shunichiro Fujiyama,Tetsuya Hosaka,Satoshi Saitoh,Hitomi Sezaki,Norio Akuta,Fumitaka Suzuki,Yoshiyuki Suzuki,Kenji Ikeda,Yasuji Arase,Masaji Hashimoto,Hiromitsu Kumada
出处
期刊:Liver cancer
[S. Karger AG]
日期:2019-11-13
卷期号:9 (1): 84-92
被引量:28
摘要
This study aimed to identify the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) as a predictor of the response of hepatocellular carcinoma (HCC) to lenvatinib.We evaluated 28 consecutive patients with HCC diagnosed by dynamic CT or magnetic resonance imaging combined with 18F-FDG-PET/CT. The tumor-to-normal liver standardized uptake value ratio (TLR) of the target tumor was measured before treatment using 18F-FDG-PET/CT, with a TLR ≥2 classified as a high potential for malignant HCC. The treatment response was evaluated 2 weeks after the initiation of lenvatinib using modified Response Evaluation Criteria in Solid Tumors.Of the 28 patients, 12 (43%) presented with a TLR ≥2. Evaluation of the treatment response at 2 weeks in these 12 patients revealed that 2 (17%) exhibited a complete response, 8 (67%) a partial response, 2 (17%) stable disease, and none with progressive disease. Therefore, 10 of the 12 patients (83%) experienced an objective response to lenvatinib. On the other hand, 7 of the 16 patients with a TLR <2 (44%) experienced an objective response. Thus, the objective response rate was higher in patients with a TLR ≥2 than in those with a TLR <2. Multivariate logistic regression analysis revealed that a TLR ≥2 (odds ratio 10.53; p = 0.028) is a useful predictor of an early objective response at 2 weeks.Patients with unresectable HCC showed a good early treatment response to lenvatinib. High TLR (≥2) may be a useful predictor of an extremely rapid treatment response.
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