微电极
致密部
多电极阵列
多巴胺
体内
神经科学
黑质
电极
安培法
材料科学
纳米技术
化学
电化学
生物
多巴胺能
生物技术
物理化学
作者
Cailing He,Mengdan Tao,Chenxi Zhang,Yifang He,Wei Xü,Yan Liu,Wanying Zhu
标识
DOI:10.1080/10408347.2020.1811946
摘要
Dopamine (DA) is an essential type of neurotransmitter in the central nervous system. DA neurons usually exist as nuclei which are mainly found in the ventral tegmental area (VTN) and substantia nigra pars compacta (SNc). Parkinson's disease, epilepsy, schizophrenia and other diseases are all related to the abnormal metabolism of DA. Compared with traditional DA detection methods such as spectrophotometry and electrophoresis, electrochemical sensing technology has high detection efficiency, high sensitivity, fast and convenient real-time detection, which is recognized as the most effective method for measuring neurotransmitters in vivo. The working electrode of an electrochemical sensor can be generally divided into the conventional electrode and the microelectrode according to its size. The microelectrode shows excellent properties such as high sensitivity, high temporal resolution, and high spatial resolution while detecting DA, which makes it possible to detect neurotransmitters in vivo. In order to further investigate the role of DA in regulating action, emotion, and cognition, and to further clarify the relationship between DA abnormalities or lack and neurological diseases such as Parkinson, more and more researchers apply microelectrode-based electrochemistry sensing technology to detect DA in vivo. This article reviews recent applications of microelectrodes and the latest researches in DA detection in vivo, focusing on the following three types of microelectrodes: (1) non-nanomaterial-modified carbon fiber microelectrodes (CFE); (2) nanomaterial-modified microelectrodes; (3) microelectrode arrays (MEA).
科研通智能强力驱动
Strongly Powered by AbleSci AI