化学
对映体
分子印迹
氨基酸
二肽
丙氨酸
酪氨酸
分子识别
组合化学
水解
药剂学
立体化学
有机化学
生物化学
分子
选择性
催化作用
药理学
医学
作者
Qianqian Zhao,Jiapei Yang,Jie Zhang,Datong Wu,Yongxin Tao,Yong Kong
出处
期刊:Analytical Chemistry
[American Chemical Society]
日期:2019-09-03
卷期号:91 (19): 12546-12552
被引量:56
标识
DOI:10.1021/acs.analchem.9b03426
摘要
Chiral recognition of l-amino acids is of significant importance due to the crucial role of l-amino acids in life sciences and pharmaceutics. In this work, a chiral sensor with capability of probing two chiral amino acids by an attractive single-template molecular imprinting strategy is introduced and used in the simultaneous chiral recognition of d/l-alanine (d/l-Ala) and d/l-tyrosine (d/l-Tyr). The assay relies on the hydrolysis of l-alanyl-l-tyrosine dipeptide doped in silica/polypyrrole (SiO2/PPy) under acidic conditions, resulting in l-Ala and l-Tyr coimprinted chiral sensor. This work opens up a new avenue for simultaneous chiral sensing of two or more chiral amino acids by incorporating only one template, circumventing the shortcomings encountered with multitemplate molecularly imprinted technology.
科研通智能强力驱动
Strongly Powered by AbleSci AI