A New Computational Approach to the Classification of Fluoroquinolones According to the Biopharmaceutical Classification System

Background: Two main factors, which have an influence on oral absorption from solid, immediate release dosage form, are solubility and permeability. These are considered the main fundamental properties that govern the rate and extent of oral absorption. The significance of these properties has been highlighted in the Biopharmaceutics Classification System (BCS). Keywords: Artificial neural networks, biopharmaceutics classification system, computational models, fluoroquinolones, molecular modeling, structure-properties relationship.