丝素
软骨
脚手架
材料科学
生物医学工程
生物材料
组织工程
软骨发生
明胶
细胞外基质
体内
丝绸
细胞生物学
纳米技术
解剖
化学
生物
复合材料
医学
生物技术
生物化学
作者
Weili Shi,Muyang Sun,Xiaoqing Hu,Bo Ren,Jin Cheng,Chenxi Li,Xiaoning Duan,Xin Fu,Jiying Zhang,Haifeng Chen,Yingfang Ao
标识
DOI:10.1002/adma.201701089
摘要
Articular cartilage repair remains a great challenge for clinicians and researchers. Recently, there emerges a promising way to achieve one-step cartilage repair in situ by combining endogenic bone marrow stem cells (BMSCs) with suitable biomaterials using a tissue engineering technique. To meet the increasing demand for cartilage tissue engineering, a structurally and functionally optimized scaffold is designed, by integrating silk fibroin with gelatin in combination with BMSC-specific-affinity peptide using 3D printing (3DP) technology. The combination ratio of silk fibroin and gelatin greatly balances the mechanical properties and degradation rate to match the newly formed cartilage. This dually optimized scaffold has shown superior performance for cartilage repair in a knee joint because it not only retains adequate BMSCs, due to efficient recruiting ability, and acts as a physical barrier for blood clots, but also provides a mechanical protection before neocartilage formation and a suitable 3D microenvironment for BMSC proliferation, differentiation, and extracellular matrix production. It appears to be a promising biomaterial for knee cartilage repair and is worthy of further investigation in large animal studies and preclinical applications. Beyond knee cartilage, this dually optimized scaffold may also serve as an ideal biomaterial for the regeneration of other joint cartilages.
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