Effects of intermittent theta burst stimulation on spasticity after spinal cord injury

痉挛 磁刺激 脊髓损伤 医学 刺激 H反射 麻醉 脊髓 改良阿什沃思量表 物理医学与康复 反射 内科学 精神科
作者
Raffaele Nardone,Patrick B. Langthaler,Andrea Orioli,Peter Höller,Yvonne Höller,Vanessa Frey,Francesco Brigo,Eugen Trinka
出处
期刊:Restorative Neurology and Neuroscience [IOS Press]
卷期号:35 (3): 287-294 被引量:25
标识
DOI:10.3233/rnn-160701
摘要

Purpose: Spasticity is a common disorder in patients with spinal cord injury (SCI). The aim of this study was to investigate whether intermittent theta burst stimulation (iTBS), a safe, non-invasive and well-tolerated protocol of excitatory repetitive transcranial magnetic stimulation (rTMS), is ef fective in modulating spasticity in SCI patients. Methods: In this randomized, double-blind, crossover, sham-controlled study, ten subjects with incomplete cervical or thoracic SCI received 10 days of daily sessions of real or sham iTBS. The H/M amplitude ratio of the Soleus H reflex, the amplitude of the motor evoked potentials (MEPs) at rest and during background contraction, as well as Modified Ashworth Scale (MAS) and the Spinal Cord Injury Assessment Tool for Spasticity (SCAT) were compared before and after the stimulation protocols. Results: Patients receiving real iTBS showed significant increased resting and active MEPs amplitude and a significant reduction of the H/M amplitude ratio. In these patients also the MAS and SCAT scores were significantly reduced after treatment. These changes persisted up to 1 week after the end of the iTBS treatment, and were not observed under the sham-TBS condition. Conclusion: These findings suggest that iTBS may be a promising therapeutic tool for the spasticity in SCI patients.
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