自愈水凝胶
软骨
组织工程
细胞外基质
生物医学工程
基质(化学分析)
材料科学
化学
解剖
医学
复合材料
高分子化学
生物化学
作者
Mei Liu,Xin Zeng,Chao Ma,Huan Yi,Zeeshan Ali,Xianbo Mou,Song Li,Yan Deng,Nongyue He
出处
期刊:Bone research
[Springer Nature]
日期:2017-05-30
卷期号:5 (1)
被引量:917
标识
DOI:10.1038/boneres.2017.14
摘要
Abstract Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.
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