光遗传学
神经科学
生物神经网络
机制(生物学)
突触可塑性
神经递质
神经可塑性
神经递质受体
神经元回路
阿尔茨海默病
神经传递
心理学
疾病
生物
受体
医学
中枢神经系统
哲学
生物化学
认识论
病理
作者
Qinghu Yang,Da Song,Hong Qing
标识
DOI:10.1016/j.neubiorev.2017.05.015
摘要
Alzheimer’s disease (AD), as a crucial neurodegenerative disorder, affects neural activities at many levels. Synaptic plasticity and neural circuits are most susceptible in AD, but the detailed mechanism is unclear. Optogenetic tools provide unprecedented spatio-temporal specificity to stimulate specific neural circuits or synaptic molecules to reveal the precise function of normal brain and mechanism of deficits in AD models. Furthermore, using optogenetics to stimulate neurons can rescue learning and memory loss caused by AD. It also has possibility to use light to control the Neurotransmitter receptors and their downstream signal pathway. These technical methods have broad therapeutic application prospect.
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