生物
互补DNA
遗传学
基因定位
基因
克隆(编程)
染色体
分子生物学
分子克隆
计算机科学
程序设计语言
作者
Hirofumi Ishii,Dong-Ho Kim,Teizo Fujita,Yuichi Endo,Shigeru Saeki,Tokuo Yamamoto
出处
期刊:Genomics
[Elsevier]
日期:1998-07-01
卷期号:51 (1): 132-135
被引量:47
标识
DOI:10.1006/geno.1998.5339
摘要
We report herein the cDNA cloning of a novel member of the low-density lipoprotein receptor (LDLR) family termed LDLR-related protein 3 (LRP3). Human and rat LRP3 cDNAs encode a 770-amino-acid type 1 membrane protein with the following regions: a putative signal sequence, two isoleucine/leucine/valine-rich regions with an RGD sequence, two ligand-binding repeat regions, a putative transmembrane region, and a proline-rich cytoplasmic region with a tyrosine-based internalization signal. Fluorescencein situhybridization of human chromosomes revealed that the human LRP3 gene mapped to chromosome bands 19q12–q13.2. LRP3 transcript was detected in a wide range of human tissues, with the highest expression in skeletal muscle and ovary. Despite the presence of the ligand-binding repeats, CHO cells transfected with LRP3 did not bind β-migrating very-low-density lipoprotein or receptor-associated protein.
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