医学
痤疮
维甲酸
银屑病
免疫系统
维生素
维生素D与神经学
骨化三醇受体
不利影响
维甲酸
异维甲酸
生物信息学
癌症研究
皮肤病科
免疫学
内科学
基因
遗传学
生物
出处
期刊:Seminars in Cutaneous Medicine and Surgery
[Frontline Medical Communications, Inc.]
日期:2012-03-01
卷期号:31 (1): 11-16
被引量:70
标识
DOI:10.1016/j.sder.2011.11.009
摘要
Vitamin A is required for the proper functioning of many important metabolic and physiologic activities, including vision, gene transcription, the immune system and skin cell differentiation. Both excessive and deficient levels of vitamin A lead to poor functioning of many human systems. The biologically active form, retinoic acid, binds to nuclear receptors that facilitate transcription that ultimately leads to it's physiological effects. Retinoids are derivatives of vitamin A that are medications used to treat acne vulgaris, psoriasis, ichthyosis (and other disorders of keratinization), skin cancer prevention as well as several bone marrow derived neoplasias. Systemic retinoids are teratogenic and have to be prescribed with caution and close oversight. Other potential adverse events are controversial. These include the relationship of retinoid derivatives in sunscreens, their effects on bone mineral density, depression and suicidal ideation and inflammatory bowel disease. These controversies will be discussed in detail.
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