幽门螺杆菌
发病机制
卡加
细菌粘附素
免疫学
癌症
生物
免疫系统
寄主因子
自噬
宿主因子
允许的
机制(生物学)
遗传学
基因
病毒
毒力
细胞凋亡
哲学
认识论
作者
Vânia Camilo,Toshiro Sugiyama,Eliette Touati
出处
期刊:Helicobacter
[Wiley]
日期:2017-09-01
卷期号:22 (S1)
被引量:303
摘要
Abstract Helicobacter pylori is responsible for the most commonly found infection in the world's population. It is the major risk factor for gastric cancer development. Numerous studies published over the last year provide new insights into the strategies employed by H. pylori to adapt to the extreme acidic conditions of the gastric environment, to establish persistent infection and to deregulate host functions, leading to gastric pathogenesis and cancer. In this review, we report recent data on the mechanisms involved in chemotaxis, on the essential role of nickel in acid resistance and gastric colonization, on the importance of adhesins and Hop proteins and on the role of Cag PAI ‐components and CagA. Among the host functions, a special focus has been made on the escape from immune response, the ability of bacteria to induce genetic instability and modulate telomeres, the mechanism of autophagy and the deregulation of micro RNA s.
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