川芎嗪
链脲佐菌素
糖尿病肾病
药理学
糖尿病
传统医学
化学
医学
内分泌学
病理
替代医学
作者
Jing Wang,Yong Liang,Xu Qiang,Yi Zhang,Li Xiao,Liang‐Yi Si
出处
期刊:Phytomedicine
[Elsevier]
日期:2011-10-01
卷期号:18 (13): 1148-1152
被引量:39
标识
DOI:10.1016/j.phymed.2011.05.003
摘要
This study was designed to investigate the protective effect of tetramethylpyrazine isolated from Ligusticum chuanxiong, a traditional Chinese medicine, on diabetic nephropathy in a rat model, and to explore the possible mechanism involved in a protective function.Diabetes was induced in male Sprague-Dawley rats by a single intraperitoneal injection of 70mg/kg of streptozotocin. One week later, 200mg/kg/day of tetramethylpyrazine was administered intragastric gavage daily for 8 weeks. Renal functions and expression of vascular endothelial growth factor were examined at 4 and 8 weeks after tetramethylpyrazine administration.Blood glucose and renal function were significantly improved in the tetramethylpyrazine-treated group compared to the untreated diabetic rats. Diabetic nephropathy resulted in an increase in the expression of vascular endothelial growth factor, while tetramethylpyrazine administration greatly decreased the expression.Our results suggest that administration of tetramethylpyrazine may reduce kidney damage caused by diabetes. This protective effect may be mediated, in part, by downregulated expression of vascular endothelial growth factor in the kidney.
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