PI3K/AKT/mTOR通路
长寿
内分泌系统
细胞老化
器官系统
表皮系统
神经科学
雷帕霉素的作用靶点
西罗莫司
免疫系统
医学
生物
信号转导
端粒
免疫学
内科学
疾病
激素
细胞生物学
老年学
病理
DNA
遗传学
作者
Yan Zhang,Jinjin Zhang,Shixuan Wang
标识
DOI:10.1016/j.arr.2021.101376
摘要
Aging can not only shorten a healthy lifespan, but can also lead to multi-organ dysfunction and failure. Anti-aging is a complex and worldwide conundrum for eliminating the various pathologies of senility. The past decade has seen great progress in the understanding of the aging-associated signaling pathways and their application for developing anti-aging approaches. Currently, some drugs can improve quality of life. The activation of mammalian target of rapamycin (mTOR) signaling is one of the core and detrimental mechanisms related to aging; rapamycin can reduce the rate of aging, improve age-related diseases by inhibiting the mTOR pathway, and prolong lifespan and healthspan effectively. However, the current evidence for rapamycin in lifespan extension and organ aging is fragmented and scattered. In this review, we summarize the efficacy and safety of rapamycin in prolonging a healthy lifespan by systematically alleviating aging in multiple organ systems, i.e., the nervous, urinary, digestive, circulatory, motor, respiratory, endocrine, reproductive, integumentary and immune systems, to provide a theoretical basis for the future clinical application of rapamycin in anti-aging.
科研通智能强力驱动
Strongly Powered by AbleSci AI