荧光
化学
水溶液中的金属离子
离子
选择性
滴定法
生物分子
光化学
组合化学
无机化学
有机化学
生物化学
量子力学
物理
催化作用
作者
Palanisamy Ravichandiran,D. S. Prabakaran,Nikhil Maroli,Ae Rhan Kim,Byung‐Hyun Park,Myung‐Kwan Han,Thiyagarajan Ramesh,P. Samuel,Dong Jin Yoo
标识
DOI:10.1016/j.jhazmat.2021.126409
摘要
The goal of the present work was to fabricate a new low-cost, easy-to-prepare, dual-channel fluorescence chemosensor comprised of acridine-diphenylacetyl moieties (NDA) to enable remarkable Sn4+ detection in water and biological medium. The resulting NDA–Sn4+ complex was utilized for the distinguished identification of Cr2O72- ions from other anions and biomolecules. These investigations involve the absorption, fluorescence, and electrochemical methods for the detection of Sn4+ and Cr2O72- ions in pure water. The mechanism for NDA-mediated Sn4+ detection was experimentally determined by FT-IR, NMR titrations, mass (ESI) analyses, and DFT calculations. The obtained results indicate that the NDA chemosensor possessed excellent performance characteristics including good water solubility and compatibility, quick response time (less than 10 s), high sensitivity (Sn4+ = 0.268 μM and Cr2O72- = 0.160 μM), and selectivity against coexisting metals, anions, amino acids, and peptides. The chemosensor NDA induced negligible toxicity in live cells and was successfully utilized as a biomarker for the tracking of Sn4+ in human normal and cancer cells. More importantly, NDA demonstrates distinguished recognition of Sn4+ in human cancer cells rather than in normal live cells. Additionally, NDA was shown to act as a mitochondria-targeted probe in FaDu cells.
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