免疫系统
佐剂
抗原
肠系膜淋巴结
抗原呈递
免疫学
生物
细胞生物学
化学
T细胞
作者
Xiaofang Zhong,Guangsheng Du,Xuanyu Wang,Yangsen Ou,Hairui Wang,Yining Zhu,Xinyan Hao,Zhiqiang Xie,Yuandong Zhang,Tao Gong,Zhirong Zhang,Xun Sun
出处
期刊:Small
[Wiley]
日期:2021-11-25
卷期号:18 (1)
被引量:10
标识
DOI:10.1002/smll.202105530
摘要
Parenteral vaccines typically can prime systemic humoral immune response, but with limited effects on cellular and mucosal immunity. Here, a subcutis-to-intestine cascade for navigating nanovaccines to address this limitation is proposed. This five-step cascade includes lymph nodes targeting, uptaken by dendritic cells (DCs), cross-presentation of antigens, increasing CCR9 expression on DCs, and driving CD103+ DCs to mesenteric lymph nodes, in short, the LUCID cascade. Specifically, mesoporous silica nanoparticles are encapsulated with antigen and adjuvant toll-like receptor 9 agonist cytosine-phosphate-guanine oligodeoxynucleotides, and further coated by a lipid bilayer containing all-trans retinoic acid. The fabricated nanovaccines efficiently process the LUCID cascade to dramatically augment cellular and mucosal immune responses. Importantly, after being vaccinated with Salmonella enterica serovar Typhimurium antigen-loaded nanovaccine, the mice generate protective immunity against challenge of S. Typhimurium. These findings reveal the efficacy of nanovaccines mediated subcutis-to-intestine cascade in simultaneously activating cellular and mucosal immune responses against mucosal infections.
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