纳米载体
药品
单宁酸
细胞质
体内
药物输送
生物物理学
材料科学
纳米技术
化学
细胞生物学
DNA
生物化学
生物
药理学
遗传学
有机化学
作者
Jinpeng Han,Yuchen Cui,Zi Gu,Dayong Yang
出处
期刊:Biomaterials
[Elsevier]
日期:2021-06-01
卷期号:273: 120846-120846
被引量:55
标识
DOI:10.1016/j.biomaterials.2021.120846
摘要
Developing nanocarrier systems with sufficient drug loading ability and efficient drug release behavior in cells is a powerful strategy to maximize therapeutic efficacies and minimize side effects of administered drugs. However, the two aspects are usually contradictory in a single nanocarrier. Herein, polyphenol-DNA nanocomplex with controllable assembly/disassembly behaviors is developed for responsive and sequential drug release in cancer cells. Programmable assembly of branched-DNA achieves multiple-gene loading, afterwards tannic acid (TA), plant-derived polyphenols as drugs mediate assembly of branched-DNA to form nanocomplex. Intracellularly, two-step disassembly process of nanocomplex enables efficient gene/drug release. Lysosomal acidic microenvironment induces the disassembly of nanocomplex to release TA and branched-DNA. Glutathione and DNase I in cytoplasm trigger the precise release of genes from branched-DNA. The efficacy of multiple-gene/chemo-therapy is demonstrated using in vitro and in vivo models. This work provides a controllable assembly/disassembly route to resolve the conflict between sufficient drug loading and efficient drug release in cells for therapeutics.
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