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Systemic immune-inflammation index predicts the severity of coronary stenosis in patients with coronary heart disease.

C反应蛋白 心肌梗塞 全身炎症 狭窄 中性粒细胞与淋巴细胞比率 冠心病 狼牙棒
作者
Yehong Liu,Ting Ye,Liang Chen,Tianhui Jin,Ying Sheng,Gangyong Wu,Gangjun Zong
出处
期刊:Coronary Artery Disease [Lippincott Williams & Wilkins]
卷期号:32 (8): 715-720 被引量:2
标识
DOI:10.1097/mca.0000000000001037
摘要

Background Coronary atherosclerosis is a systemic chronic inflammatory disease with variable occurrence and progression. Some laboratory parameters, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and C-reactive protein (CRP) level, are used to evaluate the degree of inflammation and the severity of coronary artery disease (CAD). The neutrophil*platelet/lymphocyte is a novel systemic immune-inflammation index (SII), and its relationship with the development and severity of CAD is unclear. Objective To investigate the association between the SII and the severity of CAD. Methods Three-hundred and ninety-five patients who underwent coronary angiography were enrolled; among whom, 285 patients were included in the CAD group and 110 patients were included in the non-CAD group according to the WHO guidelines. Patients with CAD were further divided according to the Gensini score into the severe coronary stenosis group and the mild coronary stenosis group. The SII was calculated using the following formula: neutrophil*platelet/lymphocyte. Results When the cutoff value of the SII was set at 439.44, the predictive power of CAD was the highest, with a sensitivity and specificity of 64.6 and 68.2%, respectively. When the cutoff value of the SII was set at 652.83, the predictive power of severe coronary stenosis was the highest, with a sensitivity and specificity of 71.0 and 86.0%, respectively. The area under the curve of the SII in predicting severe coronary stenosis was greater than that of the NLR, PLR and CRP level. Conclusion The SII is an independent risk factor for the occurrence and severity of CAD.
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