染色质
生物
组蛋白
计算生物学
嘉雅宠物
表观遗传学
遗传学
组蛋白密码
基因表达调控
DNA
染色质重塑
细胞生物学
基因
核小体
作者
Martin Lange,Santiago Demajo,Payal Jain,Luciano Di Croce
出处
期刊:Epigenomics
[Future Medicine]
日期:2011-10-01
卷期号:3 (5): 567-580
被引量:23
摘要
The introduction of new methods for genome-wide analyses of the chromatin state, together with the power of refined techniques for mass spectrometry and biochemistry, has provided an unprecedented view on the complexity of eukaryotic gene regulation. Chromatin structure, the state of histone modifications and DNA methylation are highly dynamic and subject to various levels of regulation. In addition, the subunit compositions of the protein complexes that bring about these changes appear to be assembled in a combinatorial manner that is specific for the cell type and developmental stage, providing increased specificity to these complexes. Here we discuss recent evidence regarding the combinatorial control of chromatin regulatory complexes.
科研通智能强力驱动
Strongly Powered by AbleSci AI