医学
临床药理学
药理学
调解人
分子药理学
受体
敌手
生物信息学
内科学
生物
作者
Alastair J.J. Wood,F. Estelle R. Simons,Kai Simons
标识
DOI:10.1056/nejm199406093302307
摘要
The H1-receptor antagonists are among the most widely used medications in the world. We review here the molecular basis of their action and their clinical pharmacology, efficacy in allergic disorders, and adverse effects. Although we will discuss the first-generation, relatively sedating H1-receptor antagonists briefly, we will emphasize the role of the second-generation, relatively nonsedating H1 antagonists (Figure 1) and will identify future directions for research of these agents.Molecular Basis of ActionHistamine mediates a variety of physiologic and pathologic responses in different tissues and cells and is an important chemical mediator of inflammation in . . .
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