Interpretability of the Modified Melasma Area and Severity Index (mMASI)

means for MASI were highest for those with severe MSS and the lowest for those with mild MSS (means: mild, 6.9 [95% CI, 4.9-8.8];moderate, 12.4 [95 CI, 11.1-13.7];severe, 20.2 [95% CI, 18.6-21.9]).Discussion | This study provides a framework that facilitates meaningful clinical interpretation of the numerical mMASI score.The ranges for mMASI provided herein correspond to global levels of severity using the MSS.Such categorization in MSS levels can assist clinicians in interpreting clinical trial data, severity of disease, and response to treatment.The mMASI is a simple, reliable validated tool that is a modification of the most commonly used outcome measure for melasma.This user-friendly tool can now be correlated with the newly proposed clinical ranges of severity presented in the Figure, which can be used to assist researchers in determining entry criteria for clinical trains for melasma and improvement of melasma with treatment.