化学
生物利用度
聚集诱导发射
药代动力学
多糖
小分子
纳米技术
过程(计算)
计算生物学
生化工程
药理学
生物化学
荧光
物理
工程类
操作系统
生物
医学
量子力学
材料科学
计算机科学
作者
Qingping Xiong,Haojie Shi,Shijie Li,Yao Chen,Yonglin Zhao,Yi Jing,Jun Yuan,Xiaoping Lai
标识
DOI:10.1080/07328303.2018.1430235
摘要
Clinical application of polysaccharides is severely limited by their various pending and controversial pharmacokinetics problems. Thus, it is urgent to develop accurate detection methods for polysaccharides and their metabolites. Aggregation-induced emission (AIE) is a unique photophysical phenomenon of propeller-shaped molecules. Currently, AIE has been successfully used to realize visualization for gelation process of polysaccharides, and accurate monitoring of spatiotemporal drug release of doxorubicin. In particular, authors found that aggregation event always happens during the pharmacokinetic process. Therefore, it is proposed that AIE can be a promising method for accurate detection of polysaccharides as well as elucidation of their bioavailability.
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