Nitrate-promoted Selective C–H Fluorination of Benzamides and Benzeneacetamides

A versatile and site-selective nitrate-promoted C–H bond fluorination using various weak coordinating amides as intrinsic directing groups was developed. Diverse tertiary and secondary amides underwent selective aromatic C–H bond fluorination, which features broad substrate scope, good regioselectivity, and mild conditions. Moreover, the late-stage C–H bond fluorination of the challenging benzeneacetamides via distal directing was reported for the first time.