Study on the Relationship between Diaphoretic Function of Mahuangtang and M Receptor

OBJECTIVE:To study the diaphoretic mechanisms of Mahuangtang and its relationship with M receptor.METHODS:70mice were randomized into7groups,which were treated with Mahuangtang plus atropine sulfate injection(0.1mg/kg),Mahuangtang plus atropine sulfate injection(0.4mg/kg),atropine sulfate injection(0.1mg/kg)plus Mahuang-tang,atropine sulfate injection(0.4mg/kg)plus Mahuangtang,Mahuangtang,atropine sulfate injection(0.1mg/kg)and control group(physiologic saline).The sweet gland on axillary fossa was observed by histomorphologic methods to assess its diaphoretic function30min after drug administration.RESULTS:Mahuangtang was effective for the diaphoresis,while at-ropine had inhibitory action on its diaphoretic function,but can not eliminate it completely.As the atropine dosage increased,the diaphoretic function of Mahuangtang became weaker.The diaphoretic function of Mahuangtang plus atropine group was stronger than that of atropine plus Mahuangtang group.CONCLUSIONS:The diaphortic function of Mahuangtang was rela-tive to activating M receptor,but wasn’t an only approach.