软骨细胞
软骨
细胞生物学
自体软骨细胞移植
透明软骨
祖细胞
细胞外基质
骨关节炎
体外
医学
生物
化学
病理
解剖
关节软骨
干细胞
生物化学
替代医学
作者
Li Duan,Bin Ma,Yujie Liang,Jielin Chen,Weimin Zhu,Mingtao Li,Daping Wang
出处
期刊:PubMed
日期:2015-01-01
卷期号:7 (2): 194-208
被引量:66
摘要
Autologous chondrocyte implantation (ACI) is a golden treatment for large defects of the knee joint without osteoarthritis or other complications. Despite notable progresses, generation of a stable chondrocyte phenotype using progenitor cells remains a main obstacle for chondrocyte-based cartilage treatment. Monolayer chondrocyte expansion in vitro is accompanied by chondrocyte dedifferentiation, which produces a non-specific mechanically inferior extracellular matrix (ECM) unsuitable for ACI. In-depth understanding of the molecular events during chondrocyte dedifferentiation is required to maintain the capacity of in vitro expanded chondrocytes to produce hyaline cartilage-specific ECM. This review discusses key cytokines and signaling pathways involved in chondrocyte dedifferentiation from the standpoint of catabolism and anabolism. Some potential therapeutic strategies are also presented to counteract chondrocyte dedifferentiation for cell-based cartilage therapy.
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