癌症免疫疗法
抗原
免疫疗法
免疫系统
癌症
癌症疫苗
免疫学
生物
癌症研究
病毒学
医学
遗传学
作者
Guizhi Zhu,Fuwu Zhang,Qianqian Ni,Gang Niu,Xiaoyuan Chen
出处
期刊:ACS Nano
[American Chemical Society]
日期:2017-03-09
卷期号:11 (3): 2387-2392
被引量:263
标识
DOI:10.1021/acsnano.7b00978
摘要
Vaccines hold tremendous potential for cancer immunotherapy by treating the immune system. Subunit vaccines, including molecular adjuvants and cancer-associated antigens or cancer-specific neoantigens, can elicit potent antitumor immunity. However, subunit vaccines have shown limited clinical benefit in cancer patients, which is in part attributed to inefficient vaccine delivery. In this Perspective, we discuss vaccine delivery by synthetic nanoparticles or naturally derived nanoparticles for cancer immunotherapy. Nanovaccines can efficiently codeliver adjuvants and multiepitope antigens into lymphoid organs and into antigen-presenting cells, and the intracellular release of vaccine and cross-presentation of antigens can be fine-tuned via nanovaccine engineering. Aside from peptide antigens, antigen-encoding mRNA for cancer immunotherapy delivered by nanovaccine will also be discussed.
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