还原胺化
对映选择合成
甲酸
化学
催化作用
镍
胺化
格式化
脱羧
氢化物
组合化学
有机化学
立体选择性
氢
作者
Peng Yang,Li Hui Lim,Pratanphorn Chuanprasit,Hajime Hirao,Jianrong Steve Zhou
标识
DOI:10.1002/anie.201606821
摘要
An asymmetric reductive amination of ketones using both arylamines and benzhydrazide in the presence of nickel catalysts was developed. A one-pot synthesis of tetrahydroquinoxalines was also developed starting directly from α-ketoaldehydes and 1,2-diaminobenzene. Formic acid was used as a safe and economic surrogate for high-pressure hydrogen gas. Strongly σ-donating bis(alkylphosphine)s are crucial ancillary ligands for both stereoselective hydride insertion and decarboxylation of the formate.
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