炎症性肠病
活性氧
氧化应激
结肠炎
癌症研究
炎症
疾病
医学
化学
免疫学
内科学
生物化学
作者
Chen Zhang,Han Wang,Xinhui Yang,Zi Fu,Xiuru Ji,Yifan Shi,Jie Zhong,Weiguo Hu,Youqiong Ye,Zhengting Wang,Dalong Ni
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-09-16
卷期号:8 (37)
被引量:48
标识
DOI:10.1126/sciadv.abp9882
摘要
Inflammatory bowel disease (IBD) affects millions of people each year. The overproduction of reactive oxygen species (ROS) plays a critical role in the progress of IBD and will be a potential therapeutic target. Here, we synthesize a kind of oral zero-valent-molybdenum nanodots (ZVMNs) for the treatment of IBD by scavenging ROS. These ultrasmall ZVMNs can successfully pass through the gastric acid and then be absorbed by the intestine. It has been verified that ZVMNs can down-regulate the quantity of ROS and reduce colitis in a mouse IBD model without distinct side effects. In addition, RNA sequencing reveals a further mechanism that the ZVMNs can protect colon tissues from oxidative stress by inhibiting the nuclear factor κB signaling pathway and reducing the production of excessive pro-inflammatory factors. Together, the ZVMNs will offer a promising alternative treatment option for patients suffering from IBD.
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