子痫前期
FOXP3型
调节性T细胞
免疫系统
白细胞介素2受体
免疫学
流式细胞术
怀孕
免疫耐受
医学
维生素D与神经学
内科学
维甲酸
内分泌学
男科
T细胞
生物
细胞培养
遗传学
作者
Eva Roria Silalahi,Noroyono Wibowo,Damar Prasmusinto,Ratna Djuwita,Iris Rengganis,Johanes C. Mose
标识
DOI:10.1016/j.jri.2022.103746
摘要
Immune intolerance is thought to be the underlying cause of immune rejection to fetus in preeclampsia. Decidual dendritic cell-10 (DC-10) and T regulator cell (Treg) play important role to create tolerogenic environment during pregnancy. However, their roles on the specific pathomechanism of preeclampsia along with various nutritional factors have not been widely studied.To determine the number of DC-10 and Treg in preeclampsia and their correlations with decidual nutritional factors.This was a cross-sectional study among early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normotensive (NT) pregnancies. Decidual specimens were obtained by curettage after caesarean section. The number of DC-10 and Treg cells were counted using flow cytometry. The levels of nutritional factors (zinc, retinol, all-trans retinoic acid, vitamin D) were determined using ICP-MS and LC-MS method.A total of 14 subjects for each group were included in the study. The DC-10 was significantly lower in both EOPE and LOPE compared to NT (p < 0.001). Treg cells were significantly higher in EOPE compare to NT (p = 0.015). There was a moderate correlation between zinc level and DC-10 (p = 0.011) and a strong correlation between retinol level and DC-10 (p = 0.002) in the NT group. A moderate correlation was found between vitamin D level and Treg cells in the NT group (p = 0.026).There was a lower number of DC-10 and higher number of Treg cells in early preeclampsia. There was no correlation between DC-10 and Treg number with decidual nutritional factors in preeclampsia.
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