Advances in the Chemical Transformations Involving Nitroalkenes Embedded in Heterocyclic Framework

Heterocyclic nitroalkenes play a key role in synthetic organic chemistry, serving as versatile building blocks for the construction of diverse molecular architectures. Their unique reactivity arises from the combination of heterocyclic motifs and the nitroalkene functionality, which enables the facile synthesis of bioactive complex molecules. This review explores the synthetic methodologies, strategic applications of heterocyclic nitroalkenes and highlights their significance in the development of novel organic transformations. From organocatalyzed asymmetric domino reactions to metal catalyzed cycloaddition reactions, dearomatization and annulations, these compounds contribute to synthesizing biologically relevant compounds and functional materials, showcasing their indispensable role in advancing the frontiers of synthetic organic chemistry.