乙型肝炎病毒
细胞毒性T细胞
维生素D与神经学
免疫学
T细胞
乙型肝炎
细胞
体外
医学
内科学
生物
病毒
病毒学
免疫系统
遗传学
生物化学
作者
Ké Li,Eying Lu,Qin Wang,Ruirong Xu,Wenhui Yuan,Ruan Wu,Ligong Lu,Yunfei Gao
出处
期刊:Immunology
[Wiley]
日期:2023-09-13
卷期号:171 (1): 31-44
摘要
Previous studies have demonstrated that T cell exhaustion is associated with poor clearance of Hepatitis B virus (HBV). However, whether the expression of exhaustion markers on innate-like circulating γδ T cells derived from patients with HBV infection correlates with the serum level of vitamin D is not completely understood. In this study, we found that the frequency of circulating Vδ2+ T cell and serum levels of vitamin 25(OH)D3 were significantly decreased in patients with HBV. And serum 25(OH)D3 levels in HBV-infected patients were negatively correlated with HBV DNA load and PD-1 expression on γδ T cells. Interestingly, 1α,25(OH)2 D3 alleviated the exhaustion phenotype of Vδ2 T cells in HBV-infected patients and promoted IFN-β expression in human cytotoxic Vδ2 T cells in vitro. Collectively, these findings demonstrate that vitamin D plays a pivotal role in reversing γδ T-cell exhaustion and is highly promising target for ameliorating HBV infection.
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