Platelet lifespan and mechanisms for clearance

血小板 间隙 唾液酸 血小板活化 病理生理学 免疫学 医学 内科学 生物 生物化学 泌尿科
作者
Olga An,Carsten Deppermann
出处
期刊:Current Opinion in Hematology [Ovid Technologies (Wolters Kluwer)]
卷期号:31 (1): 6-15 被引量:9
标识
DOI:10.1097/moh.0000000000000792
摘要

Purpose of review Activated or aged platelets are removed from circulation under (patho)physiologic conditions, the exact mechanism of platelet clearance under such conditions remains unclear and are currently being investigated. This review focuses on recent findings and controversies regarding platelet clearance and the disruption of platelet life cycle. Recent findings The platelet life span is determined by glycosylation of platelet surface receptors with sialic acid. Recently, it was shown that platelet activation and granule release leads to desialylation of glycans and accelerated clearance of platelets under pathological conditions. This phenomenon was demonstrated to be a main reason for thrombocytopenia being a complication in several infections and immune disorders. Summary Although we have recently gained some insight into how aged platelets are cleared from circulation, we are still not seeing the full picture. Further investigations of the platelet clearance pathways under pathophysiologic conditions are needed as well as studies to unravel the connection between platelet clearance and platelet production.
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